In the town of Ogden Marsh, Iowa, David Dutton, the sheriff, is
enjoying a baseball game when it is interrupted by resident Rory entering the
outfield with a shotgun. David attempts to dissuade him, but is forced to kill
him when he raises his weapon. David's wife Judy, the community doctor, has
begun to notice another resident exhibiting bizarre behavior, including
lifeless and repetitive speech. The next night, a local farmer locks his wife
and son inside their farmhouse and burns it down.
Following the discovery of a pilot's body in a swamp, David and
his deputy Russell investigate the area. They discover a military aircraft that
crashed into the river a few days before. Suspecting a link between the
contaminated water and the residents' bizarre behavior, David lobbies Mayor
Hobbs to shut off the town's drinking water supply. He is denied, but does so
anyway.
Soon after, all communication services are lost in town and
soldiers arrive to quarantine all residents at a high school. The residents are
examined for symptoms of infection, and Judy does not pass the examination due
to elevated temperature because of her pregnancy and is separated from David.
David escapes quarantine and returns to his office, encountering Russell. The
pair head for the school to free Judy. At the school, infected townspeople
breach the perimeter, and the military personnel evacuate, abandoning the
civilians. Judy wakes up strapped to a gurney alongside several others, and
school director Ben Sandborn enters and begins killing quarantined people.
David and Russell arrive and kill Ben, freeing her and Becca, Judy's assistant.
Unable to find a working vehicle, the four make their way out of
town on foot. They encounter Becca's boyfriend Scotty at his farm. Soldiers
raid the farm, shoot Scotty and his mother, and burn their bodies. David
subdues a soldier and learns that the military has been ordered to shoot all
civilians. The group repairs a patrol car in David's garage and are ambushed in
David's house by Rory's infected wife Peggy and son Curt. Peggy stabs David in
the hand before he kills her, and Russell shoots Curt through a window. Russell
shoots the pair's corpses multiple times, disturbing Judy.
David, Judy, Becca, and Russell flee in a car. On the road, they
are spotted by an attack helicopter and drive into a car wash for cover.
Employees at the car wash attack the car and drag Becca out by the neck with a
hose, breaking her neck and killing her. When the rest of the group leaves the
car to help her, the helicopter destroys the car.
While walking down the road, the group spots a black SUV
speeding toward them, which Russell disables with a police spike strip. The
driver, a government employee, reveals that the cargo plane contained a
Rhabdoviridae prototype and biological weapon called Trixie. It was en route to
Texas to be destroyed when the plane crashed. Enraged, Russell shoots him and
threatens the Duttons. David confronts him about his behavior, and Russell
realizes he is infected. Russell begs to continue with them. At a military
roadblock, Russell distracts the soldiers and is killed, allowing the Duttons
to sneak past.
David and Judy arrive at a truck stop to search for a vehicle,
discovering that the military has also executed those who were evacuated. After
killing more infected, they escape in a semi-truck. As they drive away, a
massive explosion destroys Ogden Marsh and disables their truck, forcing them
to continue on foot. A view from a military satellite highlights the couple and
then the city, and the words "Initiate containment protocol" appear,
signifying a new containment task.



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