On a school trip, high school senior Peter Parker visits
a Columbia University genetics laboratory with his friend Harry
Osborn and his crush Mary Jane Watson. There, a genetically
engineered "super-spider" bites him and he falls ill after
returning home. Meanwhile, Harry's scientist father Norman Osborn, founder
and owner of Oscorp, tries to secure an important military contract. He
experiments on himself with an unstable performance-enhancing chemical and goes
insane, killing his assistant.
The next day, Peter finds he is no longer near-sighted and has
developed spider-like abilities. He can also shoot webs out of his wrists and
has quick reflexes, superhuman speed and strength, and a heightened ability to
sense danger. Brushing off his Uncle Ben's advice that "with great
power comes great responsibility", Peter considers impressing Mary Jane
with a car. He enters an underground wrestling tournament to win the
money for it and wins his first match against Bonesaw McGraw, but the
promoter cheats him out of his earnings. When a burglar robs the
promoter's office, Peter allows him to escape in retaliation. Moments later, he
discovers Ben was carjacked and killed by a robber with a handgun. Peter
pursues the carjacker, only to realize it was the robber he let escape. The
carjacker flees but dies after falling out a window. Meanwhile, a crazed Norman
interrupts a military experiment by Oscorp's corporate rival Quest Aerospace and
kills several people.
Upon graduating, Peter begins using his abilities to fight
injustice, donning a spandex costume and the persona of Spider-Man. J.
Jonah Jameson, publisher of the Daily Bugle newspaper, hires
Peter as a freelance photographer, since he is the only person
providing clear images of Spider-Man. Norman, upon discovering Oscorp's board
plans to oust him in order to sell the company to Quest, assassinates them.
Jameson dubs the mysterious killer the "Green Goblin".
The Goblin offers Spider-Man a place at his side, but Peter
refuses. They fight and Peter is wounded. At Thanksgiving dinner, Peter's Aunt
May invites Mary Jane, Harry, and Norman. During the dinner, Norman sees
the wound and realizes Peter's identity. Thinking the only way to defeat Peter
is to attack those special to him, Norman later attacks May, forcing her to be
hospitalized.
Harry, who is dating Mary Jane, sees her holding Peter's hand to
comfort him and presumes she has feelings for him. Devastated, Harry tells his
father that Peter loves Mary Jane, unknowingly revealing Spider-Man's biggest
weakness. Norman holds Mary Jane and a Roosevelt Island Tram car full
of children hostage alongside the Queensboro Bridge. He forces Peter to
choose whom he wants to save and drops them both. Peter saves both Mary Jane
and the tram car. Norman then throws him into an abandoned building and
brutally beats him. When the Goblin says how he shall kill MJ, Peter regains
his strength and gains the upper hand. Norman reveals himself to Peter and begs
for forgiveness while subtly getting his glider ready to impale Peter
from behind. Warned by his spider-sense, Peter dodges the attack and the glider
impales Norman instead. Norman tells Peter not to reveal his identity as the
Goblin to Harry before dying. Peter takes Norman's body back to the Osborn
house just as Harry walks in and, believing Spider-Man to have killed his
father, pulls a gun on him, but he escapes.



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