In a flashback, baby Charlene "Charlie" McGee sits in her crib, spontaneously setting the room ablaze with her pyrokinesis power and sending her father Andrew "Andy" McGee into a panic. In another flashback, a young Andy and his girlfriend Victoria "Vicky" Tomlinson talk to a doctor in a clinical trial, who explains to them that they will be injected with the experimental chemical drug Lot-6, which secretly gives them supernatural powers: Andy gains telepathy, and Vicky obtains telekinesis.
In the present day, Charlie is
sitting at the kitchen table after having a nightmare. Her parents join her and
Charlie explains that she has been repressing something bad, her powers
becoming more unstable. She unintentionally causes a ruckus at her school after
exploding a bathroom stall due to anger at being bullied. Andy is shown using
his power, "the push", to influence a client to stop smoking,
although the strain causes his eyes to bleed.
Meanwhile, in a secret facility,
Captain Jane Hollister, leader of the DSI, is monitoring thermal signatures
caused by Charlie's outbursts. She visits Doctor Joseph Wanless, creator of
Lot-6 and the resulting superhumans, who implores Hollister to terminate
Charlie before her powers become uncontrollable. Hollister enlists fellow
superhuman John Rainbird to assist her. Rainbird visits the McGee home,
confronting Vicky who attempts to counterattack with her repressed telekinetic
powers. Rainbird overpowers and kills her, holding Charlie at knifepoint as she
and Andy enter the home. Charlie's powers overwhelm her and she sends a
concussive burst of flames throughout the house. Andy and Charlie escape into
their truck.
On the road, they encounter a man
named Irv. After using the push to convince Irv to take them to Boston,
they hitch a ride with him, stopping off at his house. After Charlie
accidentally stumbles upon his paralyzed wife, Irv flies into a rage before
conceding that he occasionally overreacts. Irv sits up all night watching a
news report of the incident at the McGee home, which is being framed as murder
by Andy. Irv and Andy argue before Andy explains to Irv that he is just trying
to protect his daughter. Charlie telepathically tells Irv that his wife
forgives him for the accident that left her paralysed, causing him to relent
and attempt to protect Andy and Charlie when the police appear due to his prior
emergency call. Rainbird appears in the bushes, kills the policemen, and then
shoots Irv in the knee before black trucks roll in to pick up Charlie and Andy.
Andy uses his push one last time to trick Rainbird so Charlie can escape to a
forest. Charlie spends time honing her fire powers before stealing a bike and
clothes to follow her father's telepathic message to her from his cell at DSI.
Charlie finds DSI and takes an
agent's pass from him. He pleads for her not to kill him and tells her he
doesn't have a gun. She kills him after he draws the gun to attack her. She
follows a large staircase down to the restricted area where her father is being
kept. She reaches her father's glass-fronted cell, from inside which Captain
Hollister tells her not to try and burn her, lest she burns her father in the
process. Andy tells Charlie that Rainbird, not he, telepathically called for
her. Seeing no other way out, he apologizes to her and then mentally pushes her
to burn the entire place down, starting with Hollister and himself. Charlie
sets both on fire, mentally unlocks all the security doors, and walks through
the facility killing everyone. Rainbird is released when his holding cell is
unlocked. Charlie is captured by men in fire suits, unable to kill them all.
The men are about to subdue her when Rainbird shoots them from behind. He
surrenders to Charlie and kneels for her judgment. Charlie starts to kill him
but sees herself in the mirror and, realizing that the DSI is also controlling
him, she spares him, before finally burning the rest of the building down.
Lastly, Charlie is seen walking onto a beach with Rainbird following behind.
Knowing that she is alone in the world, Charlie allows Rainbird to carry her,
and they walk off together.



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