War veteran Will Sharp, desperately in need of $231,000 for his wife Amy's surgery, reaches out to Danny, his adoptive brother and a life-long criminal, who talks him into taking part in a $32 million bank heist. Though initially hesitant, Will agrees after Danny reaffirms that he is doing this for Amy. The plan nearly succeeds until Officer Zach, who goes to the bank to ask out a bank teller, discovers the situation and is held hostage by Danny. A shootout then occurs between one of the heist members and Zach's partner Officer Mark. The Special Investigation Section (SIS) of the LAPD arrives and shoots down the whole crew except Will and Danny, who retreat towards the garage. Zach attempts to escape and during a scuffle between him and Danny, he is accidentally shot by Will. Leaving Zach to die, the brothers attempt to exit through the back of the building but find it surrounded by police. They then hijack an ambulance with EMT Cam Thompson on board, who is treating the injured Zach. After a chase that leads them into an alleyway, Cam makes a desperate attempt to escape using a fire extinguisher but decides to stay when Zach starts flatlining.
SIS Captain Monroe arrives on the
scene and deploys helicopters to chase after the ambulance. Cam gets Danny to
help her use a defibrillator and Will to transfer some of his blood to Zach,
much to his confusion and frustration. Danny then calls Papi, one of his
father's criminal friends, for help losing the police in exchange for $8
million. When Cam stops Danny from shooting Mark, who has been chasing them,
Danny threatens to throw her off the ambulance. The police are forced to
retreat when it is discovered that Monroe's dog is inside Mark's police
vehicle. FBI Agent Anson Clark, a past friend of Danny's, is put on the case.
Zach begins to bleed out; Cam, with Will's assistance, begins to perform
surgery on Zach. Despite her inexperience and a ruptured spleen, Cam
successfully performs the surgery. Cam tries to convince Will to stop Danny to
no avail. Monroe, unaware of the surgery's success, moves forward with the
operation and prepares to snipe Will and Danny without negotiating for Cam's
life. Clark calls Cam and tells her to get down. Cam, wanting to save Zach's
life, alerts Will and Danny about the snipers. Danny, having had enough of Cam,
decides to shoot her but Will intervenes, causing the brothers to fight about
their predicament. They later partially reconcile and listen to music together
to ease the tension.
In the Los Angeles River,
helicopters chase the ambulance as Danny shoots at them. Will and Danny then
drive on the opposite lane of the interstate, creating multiple accidents. On
Papi's orders, his son, Roberto, drives an empty ambulance towards the police
after filling it with C-4 explosives and deploys machine guns on
separate cars to cause additional damage, which ends up killing Monroe in the
crossfire. Mark chases down Roberto and kills him after a scuffle, leaving Papi
angry and distraught. Will and Danny escape to Papi's hideout. Papi demands the
brothers to leave Zach and Cam with them to deal with; Will refuses to
cooperate and teams up with Danny to kill Papi and his crew. In the chaos, Cam
accidentally shoots Will using Zach's gun. Danny takes the ambulance to a
hospital and discovers Zach's gun. He is enraged when Cam reveals that she was
the one who shot Will. Danny vows to kill Cam along with himself on live
television, before confronting the police. Will, left with no other choice,
shoots Danny in the back. Danny apologizes to Will before he dies from his
injuries. The police arrest a heavily-injured Will and take him inside for
surgery, Cam secretly gives some of the heist money to Amy for her surgery, and
Zach, when questioned by the police about his injuries, tells them that Will saved
his life.


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